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Article

Pharmacogenetics of Olanzapine Metabolism

1 Aug 2013

Abstract excerpt

The pharmacokinetics of the atypical antipsychotic, olanzapine, display large interindividual variation leading to multiple-fold differences in drug exposure between patients at a given dose. This variation in turn gives rise to the need for individualized dosing in order to avoid concentration-dependent adverse effects or therapeutic failure. Genetically determined differences in olanzapine metabolism represent...

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PMID: 23930678
DOI: 10.2217/pgs.13.120

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