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Article

Olanzapine metabolism and the significance of UGT1A448V and UGT2B1067Y variants.

Pharmacogenetics and genomics - 1 Sept 2011

Erickson-Ridout Kathryn Kelly, Zhu Junjia, Lazarus Philip

Abstract excerpt

OBJECTIVES: Olanzapine is an antipsychotic used in the treatment of schizophrenia, bipolar disorder, and treatment-resistant depression. Glucuronidation by the UDP-glucuronosyltransferase (UGT) family of enzymes is the major mode of olanzapine metabolism, and polymorphisms in these enzymes could contribute to interindividual variability in olanzapine metabolism and therapeutic response. METHODS: Cell lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21750471
DOI: 10.1097/FPC.0b013e328348c76b
PMCID: PMC6281394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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