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Article

Problems of reporting genetic associations with complex outcomes.

Lancet (London, England) - 8 Mar 2003

Colhoun Helen M, McKeigue Paul M, Davey Smith George

Abstract excerpt

Inability to replicate many results has led to increasing scepticism about the value of simple association study designs for detection of genetic variants contributing to common complex traits. Much attention has been drawn to the problems that might, in theory, bedevil this approach, including confounding from population structure, misclassification of outcome, and allelic heterogeneity. Other researchers have...

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Identifiers

PMID: 12642066
DOI: 10.1016/s0140-6736(03)12715-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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