Nonreplication in genetic studies of complex diseases--lessons learned from studies of osteoporosis and tentative remedies.

Abstract excerpt

Inconsistent results have accumulated in genetic studies of complex diseases/traits over the past decade. Using osteoporosis as an example, we address major potential factors for the nonreplication results and propose some potential remedies. Over the past decade, numerous linkage and association studies have been performed to search for genes predisposing to complex human diseases. However, relatively little...

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