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Article

Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes.

PloS one - 1 Jan 2011

Stringer Sven, Wray Naomi R, Kahn René S, Derks Eske M

Abstract excerpt

Complex diseases are often highly heritable. However, for many complex traits only a small proportion of the heritability can be explained by observed genetic variants in traditional genome-wide association (GWA) studies. Moreover, for some of those traits few significant SNPs have been identified. Single SNP association methods test for association at a single SNP, ignoring the effect of other SNPs. We show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22140493
DOI: 10.1371/journal.pone.0027964
PMCID: PMC3225388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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