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Article

Candidate-gene approaches for studying complex genetic traits: practical considerations.

Nature reviews. Genetics - 1 May 2002

Tabor Holly K, Risch Neil J, Myers Richard M

Abstract excerpt

Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of non-replication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that...

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PMID: 11988764
DOI: 10.1038/nrg796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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