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Article

Role of bradykinin in angiotensin-converting enzyme knockout mice.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2003

Xiao Hong D, Fuchs Sebastien, Cole Justin M, Disher Kevin M, Sutliff Roy L, Bernstein Kenneth E

Abstract excerpt

Angiotensin-converting enzyme (ACE) plays a central role in the renin-angiotensin system. Whereas ACE is responsible for the production of angiotensin II, it is also important in the elimination of bradykinin. Constitutively, the biological function of bradykinin is mediated through the bradykinin B(2) receptor. ACE knockout mice have a complicated phenotype including very low blood pressure. To investigate the...

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Source

Identifiers

PMID: 12637363
DOI: 10.1152/ajpheart.00010.2003

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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