Article
Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene.
Circulation - 18 Nov 1997
Madeddu P, Varoni M V, Palomba D, Emanueli C, Demontis M P, Glorioso N, Dessì-Fulgheri P, Sarzani R, Anania V
Abstract excerpt
BACKGROUND: To evaluate the role of kinins in the regulation of cardiovascular function, we studied the phenotype of a mouse strain with disruption of the bradykinin B2-receptor gene (Bk 2r-/-). METHODS AND RESULTS: Under basal conditions, tail-cuff blood pressure was higher in Bk2r-/- than in wild-type Bk2r+/+ and heterozygous Bk2r+/- mice (124+/-1 versus 109+/-1 and 111+/-2 mm Hg, respectively; P<.01 for both...
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