Article
Role of the bradykinin B2 receptor in the maturation of blood pressure phenotype: lesson from transgenic and knockout mice.
Immunopharmacology - 15 Oct 1999
Madeddu P, Emanueli C, Gaspa L, Salis B, Milia A F, Chao L, Chao J
Abstract excerpt
The binding of bradykinin (BK) to its B2 receptor results in a wide spectrum of biological effects including vasodilation, smooth muscle contraction and relaxation, pain, and inflammation. In order to gain a better insight into the physiological function of this potent vasoactive peptide, murine models have been created by the use of gene insertion or deletion. The results of studies using these strategies are...
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