Article
The G-to-T point mutation in codon 34 of the factor XIII gene and the risk of pre-eclampsia.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Feb 2003
Clark Peter, Freeman Dilys J, Streja Elani, Sattar Naveed, Walker Isobel D, Greer Ian A
Abstract excerpt
A G-to-T point mutation in exon 2 of the FXIII A-subunit gene results in a leucine rather than valine at amino acid position 34 of the factor XIII molecule. The presence of leucine has been associated with a reduced risk of both arterial and venous thrombosis. We examined the prevalence of this point mutation in 102 cases of pre-eclampsia and 208 matched control subjects, as inherited and acquired risk factors...
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