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Article

Association of a Common Polymorphism in the Factor XIII Gene with Myocardial Infarction

1 Jan 1998

Abstract excerpt

Factor XIII when activated by thrombin, crosslinks fibrin, however its role in thrombotic disorders is unknown. A common point mutation (G-->T) in exon 2 of the A-subunit gene which codes for an amino acid change three amino acids from the thrombin activation site (Factor XIIIVal34Leu) is a candidate for a role in the pathogenesis of acute myocardial infarction. Factor XIII genotype frequencies were determined in...

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PMID: 9459313
DOI: 10.1055/s-0037-1614250

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