Association of a common polymorphism in the factor XIII gene with venous thrombosis.

Article

Association of a common polymorphism in the factor XIII gene with venous thrombosis.

Blood - 1 Feb 1999

Catto A J, Kohler H P, Coore J, Mansfield M W, Stickland M H, Grant P J

Abstract excerpt

We have shown an association between a common mutation in the factor XIII a-subunit gene, coding for an amino acid change, 3 amino acids from the thrombin activation site (factor XIII Val34Leu) that may protect against myocardial infarction and predisposes to intracranial hemorrhage. To investiga...

Topics

Adult
Aged
Amino Acid Substitution
England
Factor V
Factor XIII
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Point Mutation
Thrombophilia
Venous Thrombosis

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