Article
The homozygous leu variant of the factor XIII Val34Leu polymorphism as a risk factor for the manifestation of thrombotic microangiopathies.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Jan 2000
Sucker Christoph, Farokhzad Firuseh, Kurschat Christine, Grabensee Bernd, Scharf Rudiger E, Zotz Rainer B, Maruhn-Debowski Beate, Hetzel Gerd R
Abstract excerpt
The 34 Leu (100T) variant of the factor XIII Val34Leu (G100T-) polymorphism slows down fibrinolysis and has been proposed as a thrombotic risk factor. In this pilot study, we enrolled 40 patients (mean age +/- SD = 38 +/- 11 years) and 728 controls to assess the role of this genetic variant for the manifestation of thrombotic microangiopathies. From the genotype prevalences, an increased manifestation risk for...
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