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Article

Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation.

European journal of human genetics : EJHG - 1 Mar 2004

Faisel Fareeza, Romppanen Eeva-Liisa, Hiltunen Mikko, Helisalmi Seppo, Laasanen Jaana, Punnonen Kari, Salonen Jukka T, Heinonen Seppo

Abstract excerpt

This study determines whether genetic variability in the gene-encoding factor V contributes to differences in pre-eclampsia susceptibility. Allele and genotype frequencies of three single-nucleotide polymorphisms (SNPs) in the factor V gene leading to nonsynonymous changes (M385T in exon 8, and R485K and R506Q (Leiden mutation) in exon 10) were studied in 133 Caucasian women with pre-eclampsia and 112 healthy...

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Identifiers

PMID: 14673478
DOI: 10.1038/sj.ejhg.5201124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation.PMID 14673478Read ↗

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