Article
Analysis of the TP53 gene in laser-microdissected glioblastoma vasculature.
Acta neuropathologica - 1 Apr 2003
Kulla Andres, Burkhardt Karim, Meyer-Puttlitz Birgit, Teesalu Tambet, Asser Toomas, Wiestler Otmar D, Becker Albert J
Abstract excerpt
Malignant transformation of human gliomas is accompanied by extensive proliferation of stromal blood vessels. Recent data suggest mesenchymal transdifferentiation of neoplastic cells in various human cancers, including colon and breast cancer as well as gliosarcoma. In this study, we have analyzed proliferating stromal blood vessels in glioblastoma multiforme for the presence of mutations in the tumor suppressor...
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