Article
Molecular analysis of microdissected de novo glioblastomas and paired astrocytic tumors.
Journal of neuropathology and experimental neurology - 1 Feb 1999
Cheng Y, Ng H K, Ding M, Zhang S F, Pang J C, Lo K W
Abstract excerpt
Glioblastoma multiforme (GBM) often displays morphological heterogeneity in that low-grade (LG) area with well-differentiated cells are commonly found adjacent to high-grade (HG) area with poorly-differentiated cells. This heterogeneity may cause difficulty in obtaining representative tumor samples. Nevertheless, the genetic composition of these cells has only been occasionally examined. In the present study, we...
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