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Article

Detection of p53 mutations in proliferating vascular cells in glioblastoma multiforme.

Journal of neurosurgery - 1 Feb 2015

Kawasoe Takuma, Takeshima Hideo, Yamashita Shinji, Mizuguchi Sohei, Fukushima Tsuyoshi, Yokogami Kiyotaka, Yamasaki Kouji

Abstract excerpt

OBJECT: Glioblastoma multiforme (GBM), one of the most aggressive tumors in humans, is highly angiogenic. However, treatment with the angiogenesis inhibitor bevacizumab has not significantly prolonged overall patient survival times. GBM resistance to angiogenesis inhibitors is attributed to multi...

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Source

Identifiers

PMID: 25415071
DOI: 10.3171/2014.10.JNS132159

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25415071-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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