p53 mutations versus EGF receptor expression in giant cell glioblastomas.

doi:10.1097/00005072-199711000-00008

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Article

p53 mutations versus EGF receptor expression in giant cell glioblastomas.

Journal of neuropathology and experimental neurology - 1 Nov 1997

Peraud A, Watanabe K, Plate K H, Yonekawa Y, Kleihues P, Ohgaki H

Abstract excerpt

Recent studies have shown that there are distinct genetic pathways leading to the most malignant astrocytic neoplasm, the glioblastoma. Primary (de novo) glioblastomas are characterized by amplification/overexpression of the EGF receptor (EGFR) and, less frequently, of the MDM2 gene. Another path...

Topics

Adult
Aged
Brain Neoplasms
Child
ErbB Receptors
Female
Genes, p53
Glioblastoma
Humans
Immunohistochemistry
Male
Middle Aged
Mutation
Tumor Suppressor Protein p53

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