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Article

p53 mutations versus EGF receptor expression in giant cell glioblastomas.

Journal of neuropathology and experimental neurology - 1 Nov 1997

Peraud A, Watanabe K, Plate K H, Yonekawa Y, Kleihues P, Ohgaki H

Abstract excerpt

Recent studies have shown that there are distinct genetic pathways leading to the most malignant astrocytic neoplasm, the glioblastoma. Primary (de novo) glioblastomas are characterized by amplification/overexpression of the EGF receptor (EGFR) and, less frequently, of the MDM2 gene. Another pathway, operative in the progression of low-grade or anaplastic astrocytomas to secondary glioblastomas, is characterized...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9370234
DOI: 10.1097/00005072-199711000-00008

Genes

EGFR
EGF
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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