Article
Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest.
Molecular cell - 1 Feb 2003
Ye Xiaofen, Franco Alexa A, Santos Hidelita, Nelson David M, Kaufman Paul D, Adams Peter D
Abstract excerpt
The S phase checkpoint protects the genome from spontaneous damage during DNA replication, although the cause of damage has been unknown. We used a dominant-negative mutant of a subunit of CAF-I, a complex that assembles newly synthesized DNA into nucleosomes, to inhibit S phase chromatin assembly and found that this induced S phase arrest. Arrest was accompanied by DNA damage and S phase checkpoint activation...
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