Article
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint.
Cell - 29 Dec 1995
Krek W, Xu G, Livingston D M
Abstract excerpt
Commitment of mammalian cells to enter S phase enables the transcription factor E2F-1 to activate certain genes whose products mediate cell cycle advance. In S phase, E2F-1 forms stable complexes with cyclin A-kinase, which in turn eliminates E2F-1DNA binding function. Here, we show that suppression of E2F-1 DNA-binding activity by cyclin A-kinase is linked to orderly S phase progression. Disruption of this...
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