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Article

Reduction of nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair.

Nucleic acids research - 1 Jan 2005

Lewis L Kevin, Karthikeyan G, Cassiano Jared, Resnick Michael A

Abstract excerpt

Assembly of new chromatin during S phase requires the histone chaperone complexes CAF-1 (Cac2p, Msi1p and Rlf2p) and RCAF (Asf1p plus acetylated histones H3 and H4). Cells lacking CAF-1 and RCAF are hypersensitive to DNA-damaging agents, such as methyl methanesulfonate and camptothecin, suggesting a possible defect in double-strand break (DSB) repair. Assays developed to quantitate repair of defined,...

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Identifiers

PMID: 16141196
DOI: 10.1093/nar/gki806
PMCID: PMC1197131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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