Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression.

Molecular and cellular biochemistry - 1 Jan 2003

Ellis Joel J, Valencia Thomas G, Zeng Hong, Roberts L Don, Deaton Rebecca A, Grant Stephen R

Abstract excerpt

The myocyte enhancer factor-2 (MEF2) family of transcription factors regulates transcription of muscle-dependent genes in cardiac, skeletal and smooth muscle. They are activated by calcium/calmodulin (CaM)-dependent protein kinases I and IV and silenced by CaM KIIdeltaC. MEF2 is held in an inactive form by the class II histone deacetylases (HDAC) until phosphorylated by either CaM kinase I or IV. Upon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Calmodulin-Dependent Protein Kinases

Share to Calmodulin

Share to MEF2 Transcription Factors

Share to Myogenic Regulatory Factors

Share to Phenylephrine

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 12619878

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression.PMID 12619878Read ↗

Nuclear CaMKII Isoforms as Regulators of Transcription: From Developmental to Pathological PersistenceSemantic proximity Read ↗

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.Semantic proximity Read ↗

Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.Semantic proximity Read ↗

Phosphorylation at Ser²⁶ in the ATP-binding site of Ca²⁺/calmodulin-dependent kinase II as a mechanism for switching off the kinase activity.Semantic proximity Read ↗

Modulation of vascular smooth muscle cell migration by calcium/ calmodulin-dependent protein kinase II-delta 2.Semantic proximity Read ↗

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.Semantic proximity Read ↗

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.Semantic proximity Read ↗

Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7.Semantic proximity Read ↗

Phosphomimetic mutation of a conserved serine residue in Arabidopsis thaliana 14-3-3ω suggests a regulatory role of phosphorylation in dimerization and target interactions.Semantic proximity Read ↗

HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs.Semantic proximity Read ↗

Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2.Semantic proximity Read ↗

Phosphorylation at the nuclear localization signal of Ca2+/calmodulin-dependent protein kinase II blocks its nuclear targeting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.