Article
Modulation of vascular smooth muscle cell migration by calcium/ calmodulin-dependent protein kinase II-delta 2.
American journal of physiology. Cell physiology - 1 Jun 2004
Pfleiderer Paul J, Lu Katherine Kun, Crow Michael T, Keller Rebecca S, Singer Harold A
Abstract excerpt
Previous studies demonstrated a requirement for multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in PDGF-stimulated vascular smooth muscle (VSM) cell migration. In the present study, molecular approaches were used specifically to assess the role of the predominant CaMKII isoform (delta(2) or delta(C)) on VSM cell migration. Kinase-negative (K43A) and constitutively active (T287D) mutant...
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