Article
HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs.
Cell research - 1 Oct 2011
Zheng Bin, Han Mei, Shu Ya-Nan, Li Ying-Jie, Miao Sui-Bing, Zhang Xin-Hua, Shi Hui-Jing, Zhang Tian, Wen Jin-Kun
Abstract excerpt
Abnormal proliferation of vascular smooth muscle cells (VSMCs) occurs in hypertension, atherosclerosis and restenosis after angioplasty, leading to pathophysiological vascular remodeling. As an important growth arrest gene, p21 plays critical roles in vascular remodeling. Regulation of p21 expression by retinoic acid receptor (RAR) and its ligand has important implications for control of pathological vascular...
Topics
- Acetylation
- Animals
- Casein Kinase II
- Cell Line
- Cyclin-Dependent Kinase Inhibitor p21
- Gene Expression Regulation
- Histone Deacetylase 2
- Kruppel-Like Transcription Factors
- Male
- Multiprotein Complexes
- Muscle, Smooth, Vascular
- Mutation