Article

Comparative Analysis of Right Ventricular Metabolic Reprogramming in Pre-clinical Rat Models of Severe Pulmonary Hypertension-induced Right Ventricular Failure

2022-03-25

Abstract excerpt

<h4>Background</h4> Pulmonary hypertension (PH) leads to right ventricular (RV) hypertrophy and failure (RVF). The precise mechanisms of the metabolic basis of maladaptive PH-induced RVF (PH-RVF) are yet to be fully elucidated. Here we performed a comparative analysis of RV-metabolic reprogramming in MCT and Su/Hx rat models of severe PH-RVF using targeted metabolomics and multi-omics. <h4>Methods</h4> Male Spra...

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Literature Corpus work: b582fc4e-9345-53a1-8330-b31b34774dca
DOI: 10.1101/2022.03.22.485363

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