Article
Metabolic therapy at the crossroad: how to optimize myocardial substrate utilization?
Trends in cardiovascular medicine - 1 Aug 2009
Kolwicz Stephen C, Tian Rong
Abstract excerpt
There has been growing interest in targeting myocardial substrate metabolism for the therapy of cardiovascular and metabolic diseases. This is largely based on the observation that cardiac metabolism undergoes significant changes during both physiologic and pathologic stresses. In search for an effective therapeutic strategy, recent studies have focused on the functional significance of the substrate switch in...
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