Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The TP53 gene, tobacco exposure, and lung cancer.

Human mutation - 1 Mar 2003

Toyooka Shinichi, Tsuda Toshihide, Gazdar Adi F

Abstract excerpt

Of the various genetic alterations in lung cancer, the abnormalities of the TP53 gene (p53) are among the most frequent and important events. Because of its importance, many aspects of TP53 have been studied, including preneoplastic lesions and TP53as a marker for early detection and prognosis and as a therapeutic option. We summarize recent knowledge of TP53 in lung cancer with a special emphasis on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Lung Cancer Treatments and Mutations
Share to Lung Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Risk Factors

Share to Sex Factors

Share to Smoking

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 12619108
DOI: 10.1002/humu.10177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The TP53 gene, tobacco exposure, and lung cancer.PMID 12619108Read ↗

Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers.Semantic proximity Read ↗

TP53 tumor suppressor gene: a model for investigating human mutagenesis.Semantic proximity Read ↗

Human lung cancer and p53: the interplay between mutagenesis and selection.Semantic proximity Read ↗

TP53 and mutations in human cancer.Semantic proximity Read ↗

Smoking, p53 mutation, and lung cancer.Semantic proximity Read ↗

TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation databaseSemantic proximity Read ↗

Patterns of p53 G->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smokeSemantic proximity Read ↗

TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers.Semantic proximity Read ↗

A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.Semantic proximity Read ↗

TP53 mutation spectrum in lung cancer is not different in women and men.Semantic proximity Read ↗

Etiologic value of p53 mutation spectra and differences with histology in lung cancers.Semantic proximity Read ↗

Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.