Article
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers.
Oncogene - 21 Oct 2002
Pfeifer Gerd P, Denissenko Mikhail F, Olivier Magali, Tretyakova Natalia, Hecht Stephen S, Hainaut Pierre
Abstract excerpt
It is estimated that cigarette smoking kills over 1 000 000 people each year by causing lung cancer as well as many other neoplasmas. p53 mutations are frequent in tobacco-related cancers and the mutation load is often higher in cancers from smokers than from nonsmokers. In lung cancers, the p53 mutational patterns are different between smokers and nonsmokers with an excess of G to T transversions in...
Topics
- Carcinogens
- DNA Adducts
- DNA Damage
- Genes, p53
- Humans
- Mutation
- Smoking
- Tobacco Products