Article
Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer.
The Journal of pathology - 1 Jan 1999
Bennett W P, Hussain S P, Vahakangas K H, Khan M A, Shields P G, Harris C C
Abstract excerpt
The p53 tumour suppressor gene is at the crossroads of a network of cellular pathways including cell cycle checkpoints, DNA repair, chromosomal segregation, and apoptosis. These pathways have evolved to maintain the stability of the genome during cellular stress from DNA damage, hypoxia, and activated oncogenes. The high frequency of p53 mutations in human cancer is a reflection of the importance of p53...
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