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Article

Etiologic value of p53 mutation spectra and differences with histology in lung cancers.

Cancer science - 1 Feb 2008

Shimmyo Takuo, Okada Akira, Hashimoto Takehisa, Kobayashi Yasuhito, Miyagi Youhei, Ishikawa Yuichi, Nakagawa Ken, Osada Hiroaki, Tsuchiya Eiju

Abstract excerpt

A total of 297 resected Japanese non-small cell lung cancers (74 squamous cell carcinomas and 223 adenocarcinomas) were analyzed to evaluate the validity of the p53 mutation spectrum as a fingerprint for mutagenic substances as etiological factors. Frequencies of G-->T transversions in smokers were significantly higher than in non-smokers (P = 0.003) and the average incidence of G-->T at hot spot codons of adduct...

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Source

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Identifiers

PMID: 18271927
DOI: 10.1111/j.1349-7006.2007.00686.x
PMCID: PMC11159117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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