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Article

Human lung cancer and p53: the interplay between mutagenesis and selection.

Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2000

Rodin S N, Rodin A S

Abstract excerpt

It is an almost consensus opinion that the major carcinogenic risk of tobacco smoke is in its direct mutagenic action on DNA of cancer-related genes. The key data supposedly linking smoke-induced mutations to lung cancer were obtained from the adduct spectrum of the p53 tumor suppressor gene. Results of our analysis of p53 mutations compiled from the International Agency for Research on Cancer p53 database (April...

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Identifiers

PMID: 11035769
DOI: 10.1073/pnas.180320897
PMCID: PMC17326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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