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Article

Codon 64 of K-ras gene mutation pattern in hepatocellular carcinomas induced by bleomycin and 1-nitropyrene in A/J mice.

Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 2003

Bai Feng, Nakanishi Yoichi, Takayama Koichi, Pei Xin-Hai, Inoue Koji, Harada Taishi, Izumi Miiru, Hara Nobuyuki

Abstract excerpt

Bleomycin is a radiomimetic antitumor agent with unique genotoxic properties. 1-nitropyrene is an environmental mutagen and carcinogen that undergoes both oxidative and reductive metabolism. In the present study, hepatocellular carcinomas were induced in male A/J mice by the intraperitoneal injection of bleomycin (120 mg/kg) followed by the intraperitoneal administration of 1-nitropyrene (total dose: 1,575...

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Identifiers

PMID: 12616606
DOI: 10.1002/tcm.10071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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