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Article

LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer.

Oncogene - 27 Feb 2003

Li Jie, Zhang Zhongqiu, Dai Zunyan, Plass Christoph, Morrison Carl, Wang Yian, Wiest Jonathan S, Anderson Marshall W, You Ming

Abstract excerpt

Previous observation has shown that the wild-type Kras2 allele is a suppressor of lung cancer in mice. Here we report that loss of heterozygosity (LOH) of chromosome 12p was detected in approximately 50% of human lung adenocarcinomas and large cell carcinomas, and Kras2 mutations were detected at codon 12 in approximately 40% of adenocarcinomas and large cell carcinomas. Interestingly, all of the lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 12

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Source

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Identifiers

PMID: 12606951
DOI: 10.1038/sj.onc.1206192
PMCID: PMC3438910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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