Article
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Tumori - 1 Jan 2000
Vatan Ozgur, Bilaloglu Rahmi, Tunca Berrin, Cecener Gulsah, Gebitekin Cengiz, Egeli Unal, Yakut Tahsin, Urer Nur
Abstract excerpt
AIMS AND BACKGROUND: Lung cancer is one of the most common cancers and has became a predominant cause of cancer-related death throughout the world. The k-ras codon 12 mutation, which is the most common lung cancer mutation, is found in 15 to 30% of all lung cancers. Furthermore, the p53 gene has a very important role in the biological properties of tumor cells, and it is mutated in about 50% of non-small cell...
Topics
- Adenocarcinoma
- Adult
- Aged
- Carcinoma, Adenosquamous
- Carcinoma, Large Cell
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Codon
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Lung Neoplasms