Article
Implications and prognostic value of K-ras mutation for early-stage lung cancer in women.
Journal of the National Cancer Institute - 1 Dec 1999
Nelson H H, Christiani D C, Mark E J, Wiencke J K, Wain J C, Kelsey K T
Abstract excerpt
BACKGROUND: Because there is no clear consensus as to the predictive value of K-ras gene mutation for survival in patients with lung cancer, we examined the occurrence of K-ras mutations in a large, prospective case series of non-small-cell lung cancer (NSCLC). Our goals were to define the patient characteristics associated with K-ras mutation and to determine whether mutation of this gene might be a biomarker of...
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