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Article

Evolution of complexity in the integrin adhesome

10 Aug 2009

Abstract excerpt

Integrin-mediated adhesion is as ancient as multicellularity, but it was not always as complex as it is in humans. Here, I examine the extent of conservation of 192 adhesome proteins across the genomes of nine model organisms spanning one and a half billion years of evolution. The work reveals that Rho GTPases, lipid- and serine/threonine-kinases, and phosphatases existed before integrins, but tyrosine...

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PMID: 19667126
DOI: 10.1083/jcb.200811067

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