Article

Kindlin-2 Regulates the Oncogenic Activities of Integrins and TGF-β In Triple Negative Breast Cancer Progression and Metastasis

2024-02-05

Abstract excerpt

<title>Abstract</title><p><bold>Background</bold>Kindlin-2, an adaptor protein, is dysregulated in various human cancers, including triple negative breast cancer (TNBC), where it drives tumor progression and metastasis by influencing several cancer hallmarks. One well-established role of Kindlin-2 involves the regulation of integrin signaling, achieved by directly binding to the cytoplasmic tail of the integrin β...

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Literature Corpus work: 2ec3c43f-1538-5c20-8917-5e9058869216
DOI: 10.21203/rs.3.rs-3914650/v1

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