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Article

A Gsalpha mutant designed to inhibit receptor signaling through Gs.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 1999

Iiri T, Bell S M, Baranski T J, Fujita T, Bourne H R

Abstract excerpt

Hormonal signals activate trimeric G proteins by substituting GTP for GDP bound to the G protein alpha subunit (Galpha), thereby generating two potential signaling molecules, Galpha-GTP and free Gbetagamma. The usefulness of dominant negative mutations for investigating Ras and other monomeric G proteins inspired us to create a functionally analogous dominant negative Galpha mutation. Here we describe a mutant...

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Identifiers

PMID: 9892662
DOI: 10.1073/pnas.96.2.499
PMCID: PMC15165

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Source receipt: pubmed, retrieved 7 Sept 2026.

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