Article
Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2010
Lambert Nevin A, Johnston Christopher A, Cappell Steven D, Kuravi Sudhakiranmayi, Kimple Adam J, Willard Francis S, Siderovski David P
Abstract excerpt
G-protein heterotrimers, composed of a guanine nucleotide-binding G alpha subunit and an obligate G betagamma dimer, regulate signal transduction pathways by cycling between GDP- and GTP-bound states. Signal deactivation is achieved by G alpha-mediated GTP hydrolysis (GTPase activity) which is enhanced by the GTPase-accelerating protein (GAP) activity of "regulator of G-protein signaling" (RGS) proteins. In a...
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