Article
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.
Genes & development - 1 Sept 2005
Hamada Koichi, Sasaki Takehiko, Koni Pandelakis A, Natsui Miyuki, Kishimoto Hiroyuki, Sasaki Junko, Yajima Nobuyuki, Horie Yasuo, Hasegawa Go, Naito Makoto, Miyazaki Jun-Ichi, Suda Toshio, Itoh Hiroshi, Nakao Kazuwa, Mak Tak Wah, Nakano Toru, Suzuki Akira
Abstract excerpt
PTEN is an important tumor suppressor gene. Hereditary mutation of PTEN causes tumor-susceptibility diseases such as Cowden disease. We used the Cre-loxP system to generate an endothelial cell-specific mutation of Pten (Tie2CrePten) in mice. Tie2CrePten(flox/+) mice displayed enhanced tumorigenesis due to an increase in angiogenesis driven by vascular growth factors. This effect was partially dependent on the...
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