Article
Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice.
Angiogenesis - 1 Feb 2023
Smits Patrick J, Sudduth Christopher L, Konczyk Dennis J, Cheng Yu Sheng, Vivero Matthew P, Kozakewich Harry P W, Warman Matthew L, Greene Arin K
Abstract excerpt
Extracranial arteriovenous malformation (AVM) is a congenital vascular anomaly causing disfigurement, bleeding, ulceration, and pain. Most lesions are associated with somatic MAP2K1 activating mutations in endothelial cells (ECs). The purpose of this study was to determine if EC expression of mutant activated MAP2K1 is sufficient to produce vascular malformations in mice. We generated mice with a ROSA26 allele...
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