Article
The agouti-related protein and body fatness in humans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Feb 2003
Argyropoulos G, Rankinen T, Bai F, Rice T, Province M A, Leon A S, Skinner J S, Wilmore J H, Rao D C, Bouchard C
Abstract excerpt
OBJECTIVE: The objective of this study was to examine the impact of a single nucleotide polymorphism (SNP) (-38C>T) in the promoter of the human agouti-related protein (hAgRP) gene on promoter affinity for transcription factors (TFs) and its possible association with body composition phenotypes. DESIGN: Electrophoretic mobility shift assays for the functional studies and association analyses for the population...
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