Article
Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans.
International journal of obesity (2005) - 1 Apr 2006
Bonilla C, Panguluri R K, Taliaferro-Smith L, Argyropoulos G, Chen G, Adeyemo A A, Amoah A, Owusu S, Acheampong J, Agyenim-Boateng K, Eghan B A, Oli J, Okafor G, Abbiyesuku F, Johnson T, Rufus T, Fasanmade O, Chen Y, Collins F S, Dunston G M, Rotimi C, Kittles R A
Abstract excerpt
OBJECTIVE: The role of the central melanocortin system in the development of obesity has been extensively studied. Single-nucleotide polymorphisms (SNPs) within several candidate genes have been associated with food intake and obesity-related phenotypes; however, few of these associations have been replicated. SNPs in the agouti-related protein (AGRP) gene coding (Ala67Thr, 199G/A) and promoter (-38C/T) have been...
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