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Article

Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake.

The American journal of clinical nutrition - 1 Nov 2005

Loos Ruth J F, Rankinen Tuomo, Rice Treva, Rao D C, Leon Arthur S, Skinner James S, Bouchard Claude, Argyropoulos George

Abstract excerpt

BACKGROUND: The Agouti-related protein (AGRP), an appetite modulator, induces hyperphagia when administered intracerebroventricularly or when overexpressed in transgenic mice. Exogenous administration of AGRP in rodents predisposes to high fat and high sugar intakes. OBJECTIVE: The objective was to examine the potential associations of 2 ethnic-specific polymorphisms in the AGRP gene (Ala67Thr in whites and...

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Source

Identifiers

PMID: 16280444
DOI: 10.1093/ajcn/82.5.1097

Genes

AGRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake.PMID 16280444Read ↗

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The gene structure and minimal promoter of the human agouti related protein.Semantic proximity Read ↗

Functional dimorphism of two hAgRP promoter SNPs in linkage disequilibrium.Semantic proximity Read ↗

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A rare mutation in AgRP, +79G>A, affects promoter activity.Semantic proximity Read ↗

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