Article
A polymorphism in the human agouti-related protein is associated with late-onset obesity.
The Journal of clinical endocrinology and metabolism - 1 Sept 2002
Argyropoulos George, Rankinen Tuomo, Neufeld Doni R, Rice Treva, Province Michael A, Leon Arthur S, Skinner James S, Wilmore Jack H, Rao D C, Bouchard Claude
Abstract excerpt
The mouse agouti-related protein (AGRP) is a powerful appetite effector that results in hyperphagia and the development of obesity when administered intracerebroventricularly or when overexpressed in transgenic mice. Animal studies have also shown that exogenous administration of AGRP predisposes toward hedonic intake of high fat and high sucrose diets. The human ortholog (hAGRP) maps on chromosome 16q22 and has...
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