Article
A rare mutation in AgRP, +79G>A, affects promoter activity.
European journal of clinical nutrition - 1 Jun 2007
Sözen M A, de Jonge L H M, Greenway F, Ravussin E, Smith S R, Argyropoulos G
Abstract excerpt
The agouti-related protein is a powerful orexigenic peptide. A rare mutation, +79G>A, was identified in its minimal promoter in two white carriers. Comparison of the 45-year-old male proband, who was also a carrier of the common Ala67Thr polymorphism, with an age- and weight-matching wild-type population showed marginal differences for resting metabolic rate (RMR) and body mass index. The second carrier however...
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