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Article

Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2012

Park Sungmi, Liu Xuebo, Davis Deborah R, Sigmund Curt D

Abstract excerpt

A single-nucleotide polymorphism (C/A) located within an E-box at the -20 position of the human angiotensinogen (AGT) promoter may regulate transcriptional activation through differential recruitment of the transcription factors upstream stimulatory factor (USF) 1 and 2. To study the contribution of USF1 on AGT gene expression, mice carrying a (-20C) human AGT (hAGT) transgene were bred with mice harboring a USF1...

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Source

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Identifiers

PMID: 22547438
DOI: 10.1161/HYPERTENSIONAHA.112.192971
PMCID: PMC3357008

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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