Article
A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes.
Biochemical and biophysical research communications - 21 Sept 2001
Mayfield D K, Brown A M, Page G P, Garvey W T, Shriver M D, Argyropoulos G
Abstract excerpt
The murine Agouti-Related Protein (mAGRP) is upregulated in obese and diabetic mice and can stimulate hyperphagia when overexpressed in transgenic models. Here we report upstream nucleotide sequences of the human hAGRP gene with putative recognition sites for transcription factors including a site for the STAT transactivators. A polymorphism (-38C-->T) was identified in the promoter region and the C/C genotype...
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