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Article

Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.

Cell - 7 Feb 2003

Hsieh Jen-Chih, Lee Lance, Zhang Liqun, Wefer Stephen, Brown Kristen, DeRossi Charles, Wines Mary E, Rosenquist Thomas, Holdener Bernadette C

Abstract excerpt

Specification of embryonic polarity and pattern formation in multicellular organisms requires inductive signals from neighboring cells. One approach toward understanding these interactions is to study mutations that disrupt development. Here, we demonstrate that mesd, a gene identified in the mesoderm development (mesd) deletion interval on mouse chromosome 7, is essential for specification of embryonic polarity...

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Source

Identifiers

PMID: 12581525
DOI: 10.1016/s0092-8674(03)00045-x

Genes

LRP5
MESD
LDLR
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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