Article
Development of a conditional Mesd (mesoderm development) allele for functional analysis of the low-density lipoprotein receptor-related family in defined tissues.
PloS one - 1 Jan 2013
Taibi Andrew V, Lighthouse Janet K, Grady Richard C, Shroyer Kenneth R, Holdener Bernadette C
Abstract excerpt
The Low-density lipoprotein receptor-Related Protein (LRP) family members are essential for diverse processes ranging from the regulation of gastrulation to the modulation of lipid homeostasis. Receptors in this family bind and internalize a diverse array of ligands in the extracellular matrix (ECM). As a consequence, LRPs regulate a wide variety of cellular functions including, but not limited to lipid...
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